An exploratory analysis of the phase 3 KEYNOTE-B15 trial found that ctDNA status was strongly prognostic for event-free survival regardless of treatment arm.
|Videos|June 5, 2011
Dr. Chapman Describes the Side Effects of Vemurafenib
Author(s)Paul Chapman, MD
Dr. Paul Chapman from Memorial Sloan-Kettering Cancer Center Describes the Side Effects of Vemurafenib
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Paul B. Chapman, MD, from Memorial Sloan-Kettering Cancer Center, describes the most common side effects of the drug vemurafenib (Zelboraf), which includes rashes, joint pain, and inflammation of the liver. He describes that it is very important to be followed closely by a dermatologist while taking the drug because of the possible formation of non-melanoma skin tumors, squamous cell cancer of the skin, and other benign tumors that are easily excised if caught early.
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The sacituzumab govitecan, enfortumab vedotin, and zimberelimab triplet produced early, durable responses in untreated metastatic urothelial cancer.
Surufatinib plus serplulimab and cisplatin/etoposide produced a 69.8% ORR in advanced extrapulmonary neuroendocrine carcinoma.
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Exploratory subgroup analyses of the phase 2 DOVACC trial suggested a possible signal with the triplet in HRD-negative and PARP inhibitor–naive disease.
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