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Talquetamab proved safe and effective for relapsed/refractory myeloma, even in patients with comorbidities.

Talquetamab Produces Responses in R/R Myeloma After Prior T-Cell–Directed Therapies

Clinical benefit generated from treatment with lurbinectedin plus irinotecan was noted across sensitive and resistant patient populations with SCLC.

Lurbinectedin Plus Irinotecan Is Safe, Prolongs Responses in High-Risk, Pretreated SCLC

Axi-cel administration was safe and clinically active in relapsed/refractory primary and secondary central nervous system lymphoma.

Axi-Cel Shows Safety, Clinical Activity in R/R Primary and Secondary CNS Lymphomas

The strength of mKRAS-specific T-cell responses produced by ELI-002 7P correlated with tumor biomarker responses in pancreatic and colorectal cancer. 

Amphiphile Lymph Node–Targeted Vaccine Is Safe and Bolsters T-Cell Responses in MRD+ PDAC and CRC

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Marie Hu, MD, discusses considerations for the use of CAR T-cell therapy and bispecific antibodies in relapsed/refractory diffuse large B-cell lymphoma.

CAR T-Cell Therapy vs Bispecific Antibodies: Picking an Approach in R/R DLBCL

Luspatercept elicited superior erythroid response rates and duration of RBC transfusion independence compared with epoetin alfa in lower-risk MDS.

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Minoo Battiwalla, MD, MS, discusses the impact of earlier-line FDA approvals for CAR T-cell therapies on treatment outcomes in multiple myeloma.

Quadruplet Therapy and Early-Line CAR T-Cell Therapy Approvals Mark Shifting Standards in Multiple Myeloma 

VK Gadi, MD, PhD, discusses findings from the DESTINY-Breast06 trial and the implications for hormone receptor–positive, HER2-low metastatic breast cancer.

DESTINY-Breast06 Data Reveal Another Potential Avenue for T-DXd in HR+, HER2-Low Metastatic Breast Cancer

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Novel Agents Improving Outcomes for Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm

Diagnosing Blastic Plasmacytoid Dendritic Cell Neoplasm

Videos

Sangeetha Venugopal, MD, MS, provides an overview of how patients with blastic plasmacytoid dendritic cell neoplasms (BPDCN) are diagnosed.

Andrew Lane, MD, PhD, explains that blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare blood cancer that usually presents with red to purple skin lesions and requires an expert hematopathologist to diagnose using specific immunohistochemistry markers. He notes that central nervous system involvement is more common than previously thought, so all BPDCN patients should get lumbar punctures and intrathecal chemotherapy. The treatment goal is remission followed by allogeneic stem cell transplant for possible long-term remission or cure, as no therapies alone have proven sufficient. The only FDA-approved drug is tagraxofusp, though intensive ALL-like chemotherapy remains standard.

BPDCN: A Multidisciplinary Approach to Diagnosis and Treatment

Sangeetha Venugopal, MD, MS, discusses pivekimab sunirine (PVEK), a novel CD123-targeting antibody-drug conjugate for blastic plasmacytoid dendritic cell neoplasm (BPDCN). PVEK showed promising response rates in treatment-naïve BPDCN patients in an early trial and was reasonably well-tolerated without concerning safety signals. Its FDA breakthrough therapy designation in relapsed/refractory BPDCN was based on phase 1 data suggesting good efficacy even after tagraxofusp (TAG). Early trials also support PVEK's potential in CD123+ acute myeloid leukemia, both as monotherapy and when combined with other agents like azacitidine and venetoclax.

Pivekimab Sunirine: A Novel CD123 ADC Showing Promise for BPDCN

Phyu Aung, MD, PhD, FCAP, a dermatopathologist, discusses key challenges in diagnosing and treating blastic plasmacytoid dendritic cell neoplasm (BPDCN). Definitive diagnosis is difficult given BPDCN’s heterogeneous features and frequent skin and CNS involvement. Recent advances have utilized immunophenotyping and targeted CD123, which is overexpressed on BPDCN cells. However, resistance develops with CD123 monotherapy. She notes that while testing aids BPDCN insights, more prognostic markers are needed, and emphasizes that continued cross-disciplinary research is critical to better outcomes.

Advances in Diagnosis and Targeted Therapies for BPDCN from an Expert Dermatopathologist

Dr. Andrew Lane discusses CD123-targeted therapies, particularly the antibody-drug conjugate pivekimab sunirine (PVEK), for treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN). He notes PVEK's promising response rates and safety profile from early trial data, including lower risk of concerning side effects like capillary leak syndrome that can occur with the currently approved CD123-targeting agent tagraxofusp. In closing, he emphasizes accurately diagnosing BPDCN via expert hematopathology review and referral to specialized centers taking a cross-disciplinary approach, as combining emerging CD123-directed therapies with stem cell transplant as appropriate gives the best chance for optimal BPDCN management.

Emerging CD123-Targeted Therapies for BPDCN: Pivotal Trial Insights and Future Potential

Diagnosing Blastic Plasmacytoid Dendritic Cell Neoplasm

EP: 1.Diagnosing Blastic Plasmacytoid Dendritic Cell Neoplasm

EP: 2.BPDCN: A Multidisciplinary Approach to Diagnosis and Treatment

EP: 3.Pivekimab Sunirine: A Novel CD123 ADC Showing Promise for BPDCN

EP: 4.Advances in Diagnosis and Targeted Therapies for BPDCN from an Expert Dermatopathologist

EP: 5.Emerging CD123-Targeted Therapies for BPDCN: Pivotal Trial Insights and Future Potential

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