Dr. Montal on Molecular Predictors of Recurrence With Adjuvant Sorafenib in HCC

Robert Montal, MD
Published Online: Sunday, Sep 17, 2017



Robert Montal, MD, visiting researcher, Icahn School of Medicine, Mount Sinai Hospital, discusses biomarker findings of the phase III STORM trial (BIOSTORM), which explored adjuvant treatment with sorafenib (Nexavar) in patients with hepatocellular carcinoma (HCC).

In the analysis, researchers studied 188 HCC samples from the STORM trial who who were treated with sorafenib or placebo, Montal explains. Prognostic and predictive biomarkers were analyzed by gene expression, targeted exome sequencing of drivers, and assessment of activation of MAPK signaling and angiogenesis.

Regarding prognostic variables for recurrence-free survival (RFS), independent prognostic factors were found to be positive hepatocyte pERK staining and microvascular invasion. Additionally, positive hepatocyte pERK was associated with proliferation gene signatures, poor differentiation, and Ki-67 positivity. The results did not identify biomarkers predicting recurrence prevention to sorafenib. Biomarkers related to angiogenesis, proliferation, previously proposed gene signatures or mutations were not independently associated with recurrence or prevention with sorafenib, Montal adds. However, a multi-gene signature did correlate with an improvement in RFS.

Brought to you in part by Eisai


Robert Montal, MD, visiting researcher, Icahn School of Medicine, Mount Sinai Hospital, discusses biomarker findings of the phase III STORM trial (BIOSTORM), which explored adjuvant treatment with sorafenib (Nexavar) in patients with hepatocellular carcinoma (HCC).

In the analysis, researchers studied 188 HCC samples from the STORM trial who who were treated with sorafenib or placebo, Montal explains. Prognostic and predictive biomarkers were analyzed by gene expression, targeted exome sequencing of drivers, and assessment of activation of MAPK signaling and angiogenesis.

Regarding prognostic variables for recurrence-free survival (RFS), independent prognostic factors were found to be positive hepatocyte pERK staining and microvascular invasion. Additionally, positive hepatocyte pERK was associated with proliferation gene signatures, poor differentiation, and Ki-67 positivity. The results did not identify biomarkers predicting recurrence prevention to sorafenib. Biomarkers related to angiogenesis, proliferation, previously proposed gene signatures or mutations were not independently associated with recurrence or prevention with sorafenib, Montal adds. However, a multi-gene signature did correlate with an improvement in RFS.

Brought to you in part by Eisai

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