Bringing the Oncology Community Together

Dr. Durie on a More Sensitive Automated Flow Cytometry MRD Test

Brian G.M. Durie, MD
Published Online: Monday, December 16, 2013
Brian G.M. Durie, MD, chairman, International Myeloma Foundation, hematologist/oncologist, Cedars-Sinai Medical Center, Los Angeles, California, discusses a more sensitive automated flow cytometry minimal residual disease (MRD) test.

Durie says there is an automated flow cytometry MRD test that is nearly ready for commercial use. In order to develop this test, researchers went back to the drawing board and looked at the phenotype of the diverse abnormal plasma cells that are seen in the different forms of myeloma. Based on this, Durie says, the researchers came up with a cocktail of 8 antigens that identify myeloma regardless of its state or location in the body.

In addition to the cocktail, a computer software program was developed so that the read-out is not dependent on an observer. These results are analyzed using a computer algorithm, Durie says, producing an exact print out of the presence or absence of the malignant plasma cells.

Durie says this is an unexpected, major success. The sensitivity of the test is 10-5 and maybe even lower.

Related Articles
New MRD Assay Helps Move Testing Forward in Multiple Myeloma Research
An improved assay for assessing MRD status in patients with multiple myeloma is contributing to the momentum for using MRD as a surrogate endpoint for survival in clinical trials and as a tool with the potential to help guide therapy choices.
Anderson on Recent Advances in Multiple Myeloma Drugs
Pomalidomide (Pomalyst) rode impressive trial results to accelerated FDA approval this year, and Kenneth Anderson thinks it will prove a valuable new tool in the fight against multiple myeloma
B-Cell Malignancies: Transforming Expectations and Outcomes
With the arrival and incorporation into clinical practice of immunomodulatory drugs (IMiDs) and proteasome inhibitor therapy, patients with multiple myeloma are achieving deep, durable responses and disease control, and are living longer.
Most Popular Right Now
More Reading
External Resources

American Journal of Managed Care
Pharmacy Times
Physicians' Education Resource
Physician's Money Digest
Specialty Pharmacy Times
OncLive Resources

OncLive TV
Oncology Nurses
Web Exclusives

About Us
Advisory Board
Contact Us
Forgot Password
Privacy Policy
Terms & Conditions
Intellisphere, LLC
666 Plainsboro Road
Building 300
Plainsboro, NJ 08536
P: 609-716-7777
F: 609-716-4747

Copyright OncLive 2006-2014
Intellisphere, LLC. All Rights Reserved.