Dr. Esserman on the I-SPY 2 Trial in Breast Cancer
Laura Esserman, MD, MBA
Published Online: Wednesday, April 10, 2013
Laura Esserman, MD, MBA, Professor, University of California, San Francisco, comments on the findings from the I-SPY 1 trial and the basis for the I-SPY 2 trial in patients with breast cancer.
From the I-SPY 1 trial, researchers and physicians found out how to get all biomarkers off of a single core and that it was possible to work together to share data and bio-specimens. Not only did pathologic complete response translate into a better outcome for survival and recurrence, it also proved to be a much better signal for different disease subsets.
Rather than analyze subsets retrospectively, Esserman says, physicians should sort out data from the beginning to know for whom and in which subset new drugs might work.
Although the potential for next-generation sequencing of breast cancer tumors to improve treatment strategies is widely recognized, questions swirl about the optimal use of such increasingly available technologies in clinical practice for today’s patients.
A wide-ranging analysis of more than 5500 breast cancer tumors that combined genomic and protein expression testing has identified promising targets to explore for treating patients with poor prognoses, with particularly notable findings involving androgen receptor (AR) expression