Bringing the Oncology Community Together

Dr. Gradishar Discusses 10 Years of Adjuvant Tamoxifen

William J. Gradishar, MD
Published Online: Friday, January 4, 2013
William J. Gradishar, MD, Director, Maggie Daley Center for Women's Cancer Care, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, discusses results from the international ATLAS study that was presented at the 2012 San Antonio Breast Cancer Symposium.

ATLAS enrolled 6846 women with estrogen receptor-positive breast cancer who had received 5 years of prior adjuvant tamoxifen. In the trial, patients were randomized to receive no tamoxifen or an additional 5 years of treatment. Overall, those who received 10 years of tamoxifen experienced a 25% lower recurrence rate and 29% lower mortality rates. The risk of dying due to breast cancer was also lower for those receiving an additional 5 years of treatment.

Gradishar notes that a benefit for the additional treatment was not evident in years 5 to 9. The greatest benefit was observed after 10 years of treatment. Due to the current standard of care, this information may have the greatest impact for premenopausal women who are not candidates for aromatase inhibitors, Gradishar points out.

Related Articles
Phase III Clinical Trials in HER2-Positive Breast Cancer
Expert panelists explore several large clinical trials examining therapies for patients with HER2-positive breast cancer that are currently ongoing or have recently completed.
Experts Support Broader Pertuzumab Use in HER2-Positive Breast Cancer
The recent approval of pertuzumab as part of a combination neoadjuvant treatment for patients with early-stage breast cancer has paved the way for wider use of the regimen in preoperative settings.
New ASCO Guideline Expands Recommendation for SLN Biopsy Use in Early Stage Breast Cancer
An updated guideline from ASCO regarding the use of sentinel lymph node (SLN) biopsy in early stage breast cancer supports the use of the procedure over axillary lymph node dissection (ALND) in a larger group of patients than previously recommended.
Most Popular Right Now
More Reading
External Resources

American Journal of Managed Care
Pharmacy Times
Physicians' Education Resource
Physician's Money Digest
Specialty Pharmacy Times
OncLive Resources

OncLive TV
Oncology Nurses
Web Exclusives

About Us
Advisory Board
Contact Us
Forgot Password
Privacy Policy
Terms & Conditions
Intellisphere, LLC
666 Plainsboro Road
Building 300
Plainsboro, NJ 08536
P: 609-716-7777
F: 609-716-4747

Copyright OncLive 2006-2014
Intellisphere, LLC. All Rights Reserved.