Dr. Shulman on the CALGB 40101 Trial

Lawrence N. Shulman, MD
Published Online: Wednesday, November 13, 2013
Lawrence N. Shulman, MD, chief of staff, senior vice president for medical affairs, director, Center for Global Cancer Medicine, director, Department of Regional Strategy and Development, chief, Division of General Oncology, Dana-Farber Cancer Institute, discusses the results of the CALGB 40101 trial.

The trial, which compared the efficacy of adjuvant cyclophosphamide (AC) and doxorubicin versus paclitaxel, showed that paclitaxel is not equivalent to the AC combination, Shulman says.

Shulman says all statistical analyses showed that the AC combination is still the most effective treatment and that combination chemotherapy is essential. Unfortunately, Shulman says, AC is more toxic. Although the AC arm of the study had more occurrences of leukemia and cardiac death, it is still a better regimen overall.

Online CME Activities
Free CME from PER
Angiogenesis Inhibitors for Gastrointestinal Cancers: Update From the 2015 Gastrointestinal Cancers Symposium
Cancer Summaries and Commentaries™: Updates from San Francisco in Acute Myeloid Leukemia
Community Practice Connections: 9th Annual New York Lung Cancer Symposium®
Recap of SABCS 2014: Changes for Today and Hope for Tomorrow
More Reading
$auto_registration$