Jasmine Zain, MD, from the Center for the Lymphoid Malignancies, Columbia University Medical Center, discusses two ongoing trials in T-cell lymphomas.
At the Center for the Lymphoid Malignancies, researchers are currently working on combining epigenetic therapies for the treatment of T-cell lymphomas. The two agents approved in this space, vorinostat and romidepsin, both have response rates close to 30%. Zain says the goal is to improve on these response rates in the relapsed setting and even move them to the upfront setting.
Activity remains to be seen in a phase I trial looking at romidepsin and 5-azacytidine. In another trial, activity is just being observed with pralatrexate and romidepsin. Both trials are open and enrolling.