Dr. Abramson on TRANSCEND on JCAR017 Therapy in NHL

Jeremy S. Abramson, MD
Published: Monday, Jun 19, 2017



Jeremy S. Abramson, MD, clinical director, Center for Lymphoma, Massachusetts General Hospital, discusses the TRANSCEND study, which is exploring the CD19-directed chimeric antigen receptor (CAR) T-cell therapy JCAR017 in patients with relapsed/refractory aggressive B-cell non-Hodgkin lymphoma (NHL).

TRANSCEND is a phase I multicenter trial looking at the dose and safety of this cellular therapy in patients with diffuse large B-cell lymphoma and mantle cell lymphoma, Abramson says. JCAR017 has a 41BB co-stimulatory domain and a truncated EGFR receptor used to track the product in circulation and in tissue.

In the study, patients all receive a defined composition product of 1:1 of CD4 and CD8 anti-CD19 CAR T cells with JCAR017. Researchers are enrolling high-risk patients with these lymphomas who mostly are refractory to chemotherapy.


Jeremy S. Abramson, MD, clinical director, Center for Lymphoma, Massachusetts General Hospital, discusses the TRANSCEND study, which is exploring the CD19-directed chimeric antigen receptor (CAR) T-cell therapy JCAR017 in patients with relapsed/refractory aggressive B-cell non-Hodgkin lymphoma (NHL).

TRANSCEND is a phase I multicenter trial looking at the dose and safety of this cellular therapy in patients with diffuse large B-cell lymphoma and mantle cell lymphoma, Abramson says. JCAR017 has a 41BB co-stimulatory domain and a truncated EGFR receptor used to track the product in circulation and in tissue.

In the study, patients all receive a defined composition product of 1:1 of CD4 and CD8 anti-CD19 CAR T cells with JCAR017. Researchers are enrolling high-risk patients with these lymphomas who mostly are refractory to chemotherapy.

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