Dr. Francesco Forconi on B-cell Receptor Structure and Function in CLL

Francesco Forconi, MD
Published: Wednesday, Jul 06, 2016

 
Francesco Forconi, MD, associate professor of Hematology, University of Southampton, United Kingdom, discusses the role of the B-cell receptor (BCR) in chronic lymphocytic leukemia (CLL).
 
CLL is a disease with a very variable outcome, says Forconi.  It was recently published that the ability of CLL to progress depends on the BCR immunoglobulin (IgM) levels and the BCR signaling levels. Those cells that have a stronger capacity through IgM will progress more rapidly than those that have low IgM signaling capacity or lower IgM levels.  
 
By targeting this molecule it may be possible to improve outcomes, says Forconi. A better understanding of how the BCR functions in CLL will make it easier to design a therapeutic regimen to fight the disease, he says.
 
Francesco Forconi, MD, associate professor of Hematology, University of Southampton, United Kingdom, discusses the role of the B-cell receptor (BCR) in chronic lymphocytic leukemia (CLL).
 
CLL is a disease with a very variable outcome, says Forconi.  It was recently published that the ability of CLL to progress depends on the BCR immunoglobulin (IgM) levels and the BCR signaling levels. Those cells that have a stronger capacity through IgM will progress more rapidly than those that have low IgM signaling capacity or lower IgM levels.  
 
By targeting this molecule it may be possible to improve outcomes, says Forconi. A better understanding of how the BCR functions in CLL will make it easier to design a therapeutic regimen to fight the disease, he says.

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Oncology Best Practice™: Choosing Therapies for Patients with EGFR-Mutant Lung Cancers: More Options... More Decisions... Better OutcomesFeb 28, 20182.0
Clinical Vignette Series: 34th Annual Chemotherapy Foundation Symposium: Innovative Cancer Therapy for Tomorrow®Feb 28, 20182.0
Publication Bottom Border
Border Publication
x