Dr. Higano Discusses PARP Inhibitors in Prostate Cancer

Celestia Higano, MD
Published: Tuesday, Apr 25, 2017



Celestia Higano, MD, professor of medicine and urology at the University of Washington, and a member of the Clinical Research Division at Fred Hutchinson Cancer Research Center, discusses PARP inhibitors in prostate cancer.

In ovarian cancer, PARP inhibitors have been effective in patients with DNA repair defects. About one-quarter of patients with metastatic prostate cancer have DNA damage alterations, says Higano, suggesting that PARP inhibitors may be effective in this population.

Recently, olaparib (Lynparza) has shown promise in prostate cancer, with a high response rate in a recent small study.
 


Celestia Higano, MD, professor of medicine and urology at the University of Washington, and a member of the Clinical Research Division at Fred Hutchinson Cancer Research Center, discusses PARP inhibitors in prostate cancer.

In ovarian cancer, PARP inhibitors have been effective in patients with DNA repair defects. About one-quarter of patients with metastatic prostate cancer have DNA damage alterations, says Higano, suggesting that PARP inhibitors may be effective in this population.

Recently, olaparib (Lynparza) has shown promise in prostate cancer, with a high response rate in a recent small study.
 

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Clinical Vignette Series: 34th Annual Chemotherapy Foundation Symposium: Innovative Cancer Therapy for Tomorrow®Feb 28, 20182.0
Community Practice Connections™: Personalized Sequencing in Castration-Resistant Prostate Cancer: Bridging the Latest Evidence to the Bedside in Clinical ManagementAug 25, 20181.5
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