Dr. Pal on the CheckMate-214 and CABOSUN Studies in RCC

Sumanta Kumar Pal, MD
Published: Friday, Oct 13, 2017



Sumanta Kumar Pal, MD, co-director of the Kidney Cancer Program at the City of Hope in Duarte, California, discusses the CheckMate-214 and CABOSUN trials for patients with renal cell carcinoma (RCC).

The randomized CheckMate-214 study investigated the combination of nivolumab (Opdivo) plus ipilimumab (Yervoy) versus sunitinib (Sutent). This study appeared to have an overall survival benefit and a benefit in response rate. There was no significant difference in terms of progression-free survival (PFS).

In contrast, the CABOSUN study randomized patients to sunitinib or cabozantinib (Cabometyx) and showed a benefit in terms of PFS with cabozantinib. Both cabozantinib and nivolumab plus ipilimumab showed improvement versus sunitinib.
 


Sumanta Kumar Pal, MD, co-director of the Kidney Cancer Program at the City of Hope in Duarte, California, discusses the CheckMate-214 and CABOSUN trials for patients with renal cell carcinoma (RCC).

The randomized CheckMate-214 study investigated the combination of nivolumab (Opdivo) plus ipilimumab (Yervoy) versus sunitinib (Sutent). This study appeared to have an overall survival benefit and a benefit in response rate. There was no significant difference in terms of progression-free survival (PFS).

In contrast, the CABOSUN study randomized patients to sunitinib or cabozantinib (Cabometyx) and showed a benefit in terms of PFS with cabozantinib. Both cabozantinib and nivolumab plus ipilimumab showed improvement versus sunitinib.
 

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Oncology Best Practice™: Choosing Therapies for Patients with EGFR-Mutant Lung Cancers: More Options... More Decisions... Better OutcomesFeb 28, 20182.0
Clinical Vignette Series: 34th Annual Chemotherapy Foundation Symposium: Innovative Cancer Therapy for Tomorrow®Feb 28, 20182.0
Publication Bottom Border
Border Publication
x