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In the final segment, moderator, Adam M. Brufsky, MD, PhD, asks each panelist for their final thoughts on the management of metastatic breast cancer. Sara Hurvitz, MD, notes her excitement over the number of therapeutic options available to treat patients with HER2 and ER-positive breast cancer, particularly since many of these treatments have less toxicity.
The depth of understanding of tumor microenvironments and biology in breast cancer is due to a global collaboration among researchers, states Edith A. Perez, MD. Additionally, she believes, panel discussions, like this one, help to translate research into clinical practice.
Significant advances have been made in recent years in the treatment of patients with ER-positive disease, believes Hope S. Rugo, MD. Additionally, the therapies developed to treat metastatic disease are beginning to transition into the early-stage setting, representing a significant increase in the number of neoadjuvant treatments. Furthermore, Rugo adds, there is now a better understanding of the subtypes of ER-positive and overcoming resistance, which has improved outcomes for patients.
The level of competition in this space has resulted in the rapid development of novel treatments, says Joyce A. O'Shaughnessy, MD. Therapies have advanced from phase I trials quickly into phase III. In the end, this rapid development greatly benefits patients with this disease.
The treatment of breast cancer is at a tipping point, now that the biology of intrinsic subtypes has been revealed, states Andrew D. Seidman, MD. The level of molecular knowledge allows for the rational development of targeted therapeutics and combinations that avoid feedback looks that overcome therapeutic efficacy, Seidman states. Echoing this, Brufsky notes this is the beginning of the genomic era of our understanding of breast cancer, which may have implications for clinical trial design.
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Adam M. Brufsky, MD, PhD
Professor of Medicine, University of Pittsburgh
Medical Director of the Women’s Cancer Center at Magee-Womens Hospital of UPMC
and the University of Pittsburgh Cancer Institute
Sara Hurvitz, MD
Assistant Professor & Director,
Hematology/Oncology Breast Cancer Program,
UCLA's Jonsson Comprehensive Cancer Center
Los Angeles, California
Joyce A. O’Shaughnessy, MD
Co-Director, Breast Cancer Research
Baylor Charles A. Sammons Cancer Center
Texas Oncology, PA/US Oncology,
Edith A. Perez, MD
Deputy Director of the Mayo Clinic Cancer Center,
Director of the Breast Cancer Translational Genomics Program and the Breast Program at Mayo Clinic, Jacksonville, Florida
Hope S. Rugo, MD
Professor of Medicine and Director of the Breast Oncology, Clinical Trials, and Education Program, University of California San Francisco Comprehensive Cancer Center,
San Francisco, California
Andrew D. Seidman, MD
Professor of Medicine, Weill Cornell Cancer Center
Attending Physician at Memorial Sloan-Kettering Cancer Center, New York, New York