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Experts Support Broader Pertuzumab Use in HER2-Positive Breast Cancer
Experts Support Broader Pertuzumab Use in HER2-Positive Breast Cancer
The recent approval of pertuzumab as part of a combination neoadjuvant treatment for patients with early-stage breast cancer has paved the way for wider use of the regimen in preoperative settings.
New ASCO Guideline Expands Recommendation for SLN Biopsy Use in Early Stage Breast Cancer
New ASCO Guideline Expands Recommendation for SLN Biopsy Use in Early Stage Breast Cancer
An updated guideline from ASCO regarding the use of sentinel lymph node (SLN) biopsy in early stage breast cancer supports the use of the procedure over axillary lymph node dissection (ALND) in a larger group of patients than previously recommended.
I-SPY 2 Designer Describes Program’s Many Innovations
I-SPY 2 Designer Describes Program’s Many Innovations
Donald A. Berry, PhD, is a leader in the development of innovative statistical methodology for the improvement of clinical trial design and analysis, especially the Bayesian methods used in the I-SPY program.
I-SPY 2 Trial Graduates Neratinib for HER2-Positive Breast Cancer
I-SPY 2 Trial Graduates Neratinib for HER2-Positive Breast Cancer
The adaptive I-SPY 2 trial has found that a neoadjuvant regimen of neratinib and standard chemotherapy is beneficial for high-risk patients with hormone receptor (HR)-negative, HER2-positive stage II/III breast cancer
Palbociclib Improves PFS But Not OS in Updated Phase II Findings
Palbociclib Improves PFS But Not OS in Updated Phase II Findings
The combination of palbociclib and letrozole more than doubled PFS and showed a non–statistically significant 4.2-month improvement in OS for patients with ER-positive, HER2-negative metastatic breast cancer.
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