Video

Dr. Levy on Overcoming Osimertinib Resistance in EGFR-Mutant NSCLC

Benjamin P. Levy, MD, discusses potential strategies to overcome resistance to osimertinib in EGFR-mutant non–small cell lung cancer. 

Benjamin P. Levy, MD, clinical director, Medical Oncology, associate professor of oncology, Johns Hopkins Sidney Kimmel Cancer Center at Sibley Memorial Hospital, discusses potential strategies to overcome resistance to osimertinib (Tagrisso) in EGFR-mutant non–small cell lung cancer (NSCLC). 

Patients whose tumors harbor EGFR mutations often develop resistance to osimertinib. However, clinical guidelines as to what treatment is optimal for these patients are inconclusive, Levy explains. Data emerged during the 2021 ASCO Annual Meeting showing that the combination of lazertinib (YH25448) and amivantamab-vmjw (Rybrevant) elicited clinically meaningful activity in patients with chemotherapy-naïve, EGFR-mutant NSCLC who had progressed on osimertinib. The regimen has been utilized in other tumor types but offers a potential novel addition to the lung cancer armamentarium. 

Additionally, patritumab deruxtecan (U3-1402), a HER3-directed antibody-drug conjugate (ADCs), demonstrated a confirmed objective response rate of 39% in patients with EGFR-mutant NSCLC who were resistant to EGFR TKIs, Levy says. 

Moreover, the field of lung cancer treatment has evolved beyond using small molecule inhibitors to target novel targets, Levy explains. Oral therapies, bispecific antibodies, and ADCs are being developed for use in offering meaningful outcomes for patients with lung cancer, Levy concludes. 

Related Videos
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss unmet needs and future research directions in ALK-positive and ROS1-positive NSCLC.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for lorlatinib in ROS1-positive NSCLC after crizotinib and chemotherapy.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for taletrectinib in ROS1-positive advanced non–small cell lung cancer.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, on progression patterns and subsequent therapies after lorlatinib in ALK-positive NSCLC.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss preclinical CNS data for the ROS1 inhibitor zidesamtinib.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for zidesamtinib in ROS1-positive non–small cell lung cancer.
Massimo Cristofanilli, MD, attending physician, NewYork-Presbyterian Hospital; professor, medicine, Weill Cornell Medical College, Cornell University
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for NVL-655 in ALK-positive NSCLC and other ALK-positive solid tumors.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss testing for ALK-positive and ROS1-positive non–small cell lung cancer.
Nicolas Girard, MD