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Immunotherapy Impact Extends to Mesothelioma

Angelica Welch
Published: Thursday, Nov 09, 2017

We see that PD-L1, at least with this antibody, might be difficult to go to clinical practice with since it is no use for the combination therapy. We will have to study quantitatively and qualitatively the density of lymphocyte infiltration in the tumor. We have such data, we have done the study, but it is not statistically analyzed yet. We will have to see if the density of lymphocytic infiltration could add something as a biomarker to predict response. The good biomarker will ultimately be the one that predicts survival, not just response—because it is not always correlated. 

It has been a long time since a therapy has been approved in mesothelioma. Can you put into context what these recent advances mean for this disease landscape?

These trials are clearly an advance for the treatment of patients, provided that these drugs are accepted by regulatory agencies. This is a rare disease, so the development of drugs in rare diseases is different. The dose that will be submitted to the FDA will have these data for supporting registration. I believe that authorities are ready to accept such a registration with such data, and I am pretty sure these drugs will soon be available—at least in the United States. The situation could be more difficult in Europe where we may be more reluctant to register these drugs. The patients and advocacy groups will have an important role to play to support this registration.

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Online CME Activities
TitleExpiration DateCME Credits
Oncology Best Practice™: Choosing Therapies for Patients with EGFR-Mutant Lung Cancers: More Options... More Decisions... Better OutcomesFeb 28, 20182.0
Clinical Vignette Series: 34th Annual Chemotherapy Foundation Symposium: Innovative Cancer Therapy for Tomorrow®Feb 28, 20182.0
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