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|Videos|November 15, 2021

ESMO 2021: Updates in Triple Negative Breast Cancer

Author(s)Joyce A. O'Shaughnessy, MD, Sara M. Tolaney, MD, MPH, Sara A. Hurvitz, MD

Drs Joyce O’Shaughnessy, Sara Tolaney, Sara Hurvitz, and Mark Pegram examine recent trial data from ESMO 2021 on triple-negative breast cancer.

Episodes in this series

EP. 1 Updates in HER2+ Breast Cancer from ESMO 2021

EP. 1 Updates in HER2+ Breast Cancer from ESMO 2021

EP. 2 Interesting Trials in HER2+ Breast Cancer

EP. 2 Interesting Trials in HER2+ Breast Cancer

EP. 3 Updates in HR+/HER2- Breast Cancer: The MONALEESA-2 Trial

EP. 3 Updates in HR+/HER2- Breast Cancer: The MONALEESA-2 Trial

EP. 4 ESMO 2021: Updates in Triple Negative Breast Cancer

EP. 4 ESMO 2021: Updates in Triple Negative Breast Cancer

Data from the following clinical trials are discussed:

Durvalumab improves long-term outcome in TNBC: results from the phase 2 randomized GeparNUEVO study investigating neoadjuvant durvalumab in addition to an anthracycline/taxane based neoadjuvant chemotherapy in early triple-negative breast cancer (TNBC)
KEYNOTE-522: Phase 3 study of neoadjuvant pembrolizumab + chemotherapy vs placebo + chemotherapy, followed by adjuvant pembrolizumab vs placebo for early-stage TNBC - ESMO Plenary July 2021
1190 - Event-free survival (EFS), overall survival (OS), and safety of adding veliparib (V) plus carboplatin (Cb) or carboplatin alone to neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) after ≥4 years of follow-up: BrighTNess, a randomized phase 3 trial
LBA16 - KEYNOTE-355: Final results from a randomized, double-blind phase 3 study of first-line pembrolizumab + chemotherapy vs placebo + chemotherapy for metastatic TNBC
258P - Analysis of patients (pts) without an initial triple-negative breast cancer (TNBC) diagnosis (Dx) in the phase 3 ASCENT study of sacituzumab govitecan (SG) in brain metastases-negative (BMNeg) metastatic TNBC (mTNBC)

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