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Opinion|Videos|March 13, 2024

Navitoclax Plus Ruxolitinib for Untreated MF: Data From TRANSFORM-1

Author(s)Andrew Kuykendall, MD, Raajit K. Rampal, MD, PhD

Andrew Kuykendall, MD, reviews data from TRANSFORM-1 on navitoclax plus ruxolitinib for untreated myelofibrosis, highlighting consistent response rates, no significant symptom improvement with the combination, and challenges managing thrombocytopenia caused by navitoclax, despite its activity and potential as a second-line treatment option.

Episodes in this series

EP. 1 How JAK Inhibitors Have Shaped the Landscape of MF

EP. 1 How JAK Inhibitors Have Shaped the Landscape of MF

EP. 2 Pelabresib Plus Ruxolitinib for JAK Inhibitor-Naïve Patients: Data From MANIFEST and MANIFEST-2

EP. 2 Pelabresib Plus Ruxolitinib for JAK Inhibitor-Naïve Patients: Data From MANIFEST and MANIFEST-2

EP. 3 Navitoclax Plus Ruxolitinib for Untreated MF: Data From TRANSFORM-1

EP. 3 Navitoclax Plus Ruxolitinib for Untreated MF: Data From TRANSFORM-1

EP. 4 Navtemadlin Plus Ruxolitinib for Patients With MF who had Suboptimal Responses to Ruxolitinib

EP. 4 Navtemadlin Plus Ruxolitinib for Patients With MF who had Suboptimal Responses to Ruxolitinib

EP. 5 Selinexor Plus Ruxolitinib in JAK Inhibitor-Naïve Patients: Updated Results From XPORT-MF-034

EP. 5 Selinexor Plus Ruxolitinib in JAK Inhibitor-Naïve Patients: Updated Results From XPORT-MF-034

EP. 6 Luspatercept With or Without Ruxolitinib for the Treatment of Anemia in Patients With MF: Data From ACE-536-MF-001

EP. 6 Luspatercept With or Without Ruxolitinib for the Treatment of Anemia in Patients With MF: Data From ACE-536-MF-001

EP. 7 Future Directions in Combination Therapies for Myelofibrosis

EP. 7 Future Directions in Combination Therapies for Myelofibrosis

EP. 8 Key Efficacy and Safety Takeaways From Recent Data on JAK Inhibitors for MF

EP. 8 Key Efficacy and Safety Takeaways From Recent Data on JAK Inhibitors for MF

EP. 9 The FREEDOM-2 Trial: Efficacy and Safety of Fedratinib in Patients With MF Previously Treated With Ruxolitinib

EP. 9 The FREEDOM-2 Trial: Efficacy and Safety of Fedratinib in Patients With MF Previously Treated With Ruxolitinib

EP. 10 Selection and Sequencing of JAK Inhibitors for Patients With MF

EP. 10 Selection and Sequencing of JAK Inhibitors for Patients With MF

EP. 11 Individualizing Therapy Goals for Patients With Myelofibrosis

EP. 11 Individualizing Therapy Goals for Patients With Myelofibrosis

EP. 12 Emerging Treatments for Myelofibrosis

EP. 12 Emerging Treatments for Myelofibrosis

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