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Dose reductions of ribociclib plus an NSAI did not decrease the regimen’s efficacy in patients with HR-positive, HER2-negative early breast cancer. 

Ribociclib Plus NSAI Maintains Manageable Safety Profile in HR+/HER2– Early Breast Cancer

PF-07220060 plus endocrine therapy was tolerable and generated robust response rates in HR-positive, HER2-negative metastatic breast cancer.

Novel CDK4 Inhibitor Shows Activity and Safety in HR+/HER2– Metastatic Breast Cancer

Adding denosumab to neoadjuvant nab-paclitaxel did not improve 5-year invasive disease-free survival rates in patients with early-stage breast cancer.

Addition of Denosumab to Neoadjuvant Chemo Does Not Lead to Significant iDFS Differences in Early Breast Cancer

Capivasertib plus fulvestrant improved time to second progression in patients with pretreated HR-positive, HER2-negative advanced breast cancer.

Capivasertib/Fulvestrant Improves PFS2 in Pretreated PIK3CA/AKT1/PTEN+ HR+/HER2– Breast Cancer

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Sattva S. Neelapu, MD, discusses the current standing of CAR T-cell therapies in the treatment paradigm in lymphoma.

CAR T-Cell Agents Offer Efficacy in Lymphoma, But Additional Approaches Are Needed to Overcome Resistance 

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Inside the Clinic: Updates in the Prevention and Treatment of Graft versus Host Disease

Videos

Sophie Paczesny, MD, PhD, and Yi-Bin Chen, MD, discuss recent updates in the prophylactic and treatment strategies for acute and chronic graft versus host disease (GVHD).

Sophie Paczesny, MD, PhD, explains which malignancies allogeneic transplantation can be used as a potentially curative treatment approach, and which patients are best suited for transplant.

Indications for Allogeneic Stem Cell Transplantation in the Treatment of Hematological Malignancies

Dr Sophie Paczesny details the incidence of graft versus host disease (GVHD) in patients receiving allogeneic transplants, and Dr Yi-Bin Chen describes the differing risk factors for acute and chronic GVHD.

Incidence and Risk Factors of Acute and Chronic GVHD

Yi-Bin Chen, MD, shares the most common GVHD prophylaxis regimens, and which regimen he typically chooses for his patients with GVHD.

Common Prophylaxis Regimens for GVHD

Drs Yi-Bin Chen and Sophie Paczesny review the diagnosis and staging of both acute and chronic GVHD, and the challenges clinicians may encounter.

Diagnosis and Stratification of Acute and Chronic GVHD

Experts discuss the current options for treating acute GVHD, including the use of corticosteroids and their management.

Frontline Treatment Options for Acute GVHD

Sophie Paczesny, MD, PhD, and Yi-Bin Chen, MD, detail novel strategies under investigation for the treatment of acute GVHD.

Emerging Strategies for the Treatment of Acute GVHD

Drs Paczesny and Chen explain the importance of treating chronic GVHD as early as possible, and whether steroids are still the standard first-line treatment.

The Importance of Early Treatment of Chronic GVHD

Yi-Bin Chen, MD, reviews the treatment options for patients with steroid-refractory chronic GVHD.

Treatment Options for Steroid-Refractory Chronic GVHD

Drs Yi-Bin Chen and Sophie Paczesny highlight data from key investigational approaches presented at recent meetings.

Key Investigational Approaches for Acute and Chronic GVHD

Sophie Paczesny, MD, PhD, and Yi-Bin Chen, MD, share their expert perspectives on how the GVHD treatment landscape is evolving.

The Evolving Field of GVHD Treatment

Insights Video Series

The Importance of Early Treatment of Chronic GVHD

EP: 1.Indications for Allogeneic Stem Cell Transplantation in the Treatment of Hematological Malignancies

EP: 2.Incidence and Risk Factors of Acute and Chronic GVHD

EP: 3.Common Prophylaxis Regimens for GVHD

EP: 4.Diagnosis and Stratification of Acute and Chronic GVHD

EP: 5.Frontline Treatment Options for Acute GVHD

EP: 6.Emerging Strategies for the Treatment of Acute GVHD

EP: 7.The Importance of Early Treatment of Chronic GVHD

EP: 8.Treatment Options for Steroid-Refractory Chronic GVHD

EP: 9.Key Investigational Approaches for Acute and Chronic GVHD

EP: 10.The Evolving Field of GVHD Treatment

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