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2018 World Congress on GI Cancer
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Dr. O'Reilly on Immunotherapy in Pancreatic Cancer
Dr. Finn Recaps Second-Line Advancements in HCC
Dr. Demetri on Larotrectinib in TRK-Fusion GI Cancers
Oncology Conference Articles
Regorafenib Dose-Escalation Superior to Standard Dosing in mCRC
Results from the regorafenib dose optimization study (ReDOS) presented at the 2018 World Congress on GI Cancer established that the strategy of escalating regorafenib from 80 mg to 160 mg per day was superior to starting at a dose of 160 mg per day.
TAS-102 Benefit Consistent in Real-World Study for mCRC
TAS-102 (trifluridine/tipiracil; Lonsurf) continued to show consistent benefits and safety in a real-world treatment setting for patients with refractory metastatic colorectal cancer.
O'Reilly Discusses Status of Immunotherapy Research in Pancreas Cancer
Eileen M. O’Reilly, MD, speaks to the progress being made with immune therapies in pancreatic cancer.
Atezolizumab Combo Not Superior to Regorafenib for mCRC
Atezolizumab alone or in combination with cobimetinib failed to show superior overall survival compared with regorafenib for patients with chemorefractory metastatic colorectal cancer.
TAS-102 Prolongs Survival in Phase III Gastric Cancer Study
TAS-102 (trifluridine/tipiracil; Lonsurf) provided a 31% reduction in the risk of death compared with placebo in patients with heavily pretreated metastatic or advanced gastric cancer.
Pembrolizumab Fails to Show Survival Benefit in PD-L1 ≥1 Gastric/GEJ Cancers
Second-line treatment with pembrolizumab (Keytruda) did not significantly improve overall survival or progression-free survival in patients with advanced or metastatic gastric or gastroesophageal junction cancer with a PD-L1 combined positive score ≥1.
Conroy Highlights Practice-Changing Findings With Chemo Combo in Pancreatic Cancer
Thierry Conroy, MD, discusses the PRODIGE 24/CCTG PA.6 trial and shares his insight on future research with this treatment regimen.
TAS-120 Shows Promise in Cholangiocarcinoma
TAS-120 demonstrated a clinically meaningful benefit with a manageable toxicity profile in patients with cholangiocarcinoma harboring
gene fusions, including patients who had progressed on an FGFR inhibitor.
Adding SIRT Does Not Provide Survival Benefit in Advanced HCC, Except in Select Patients
Selective internal radiation therapy in combination with sorafenib (Nexavar) did not provide a significant survival improvement compared with sorafenib alone in patients with advanced hepatocellular carcinoma.
Ramucirumab Extends Survival for AFP-Elevated HCC in Pooled Analysis
Treatment with second-line ramucirumab improved median overall survival by 3.1 months compared with placebo in patients with advanced hepatocellular carcinoma with alpha-fetoprotein levels ≥400 ng/ml.
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Experts Highlight Developments in Lung, GI Cancers
CDK4/6 Inhibitors Are Transforming Treatment in HR+ Breast Cancer
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Nivolumab Combo Shows Early Activity in Relapsed/Refractory AML
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