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Dr. Engel on the Use of Eltrombopag in HIV-Related Thrombocytopenia
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Oncology Conference Articles
Expert Explains State of TKI Treatment in Pediatric CML
Discontinuation of tyrosine kinase inhibitor treatment may be a possibility for children with chronic myeloid leukemia and, because they could be on-treatment for decades, treatment-free remission is even more important for pediatric patients than for adults.
Eltrombopag Improves Platelet Count in Pediatric HIV
Eltrombopag (Promacta) boosted the platelet count in a 13-year-old boy with HIV-associated thrombocytopenia, according to case study results presented at the 2018 American Society of Pediatric Hematology/Oncology Conference.
COG to Assess Targeted Therapies in a Variety of NHL Clinical Trials
The Children's Oncology Group is currently involved in 5 studies exploring targeted therapies in non-Hodgkin lymphoma (NHL) that could eventually change the face of pediatric NHL treatment.
Tisagenlecleucel Safety, Efficacy Promising in Pediatric Down Syndrome and ALL
A first-time study of chimeric antigen receptor T-cell therapy in youths with Down syndrome-associated relapsed/refractory (r/r) acute lymphoblastic leukemia produced high remission rates and toxicity results that were similar to those observed in patients with r/r ALL.
Tazemetostat Shows Antitumor Activity in INI1-Negative Pediatric Tumors
Tazemetostat demonstrated promising antitumor activity in pediatric patients with INI1-negative solid tumors.
Selective T-Cell Depletion Improves Engraftment, Reduces GVHD in Pediatric/AYA Leukemia
Eliminating T cells carrying alpha and beta chains of the T-cell receptor reduced the risk for graft-versus-host-disease while producing "excellent" engraftment kinetics for young patients with acute leukemia who underwent hematopoietic stem cell transplant.
2B8T2M Enhances exPBNK Expression, in Vitro Cytotoxicity in Rituximab-Sensitive/Resistant Burkitt Lymphoma
2B8T2M, a fusion of the IL-15 superantagonist ALT-803, and 4 single-chains of rituximab (Rituxan) significantly boosted the cytotoxicity of expanded peripheral blood natural killer cells against Burkitt lymphoma cells in in vitro testing.
CAR T-Cell Therapy May Serve as a Bridge to HCT in ALL
CAR T-cell therapy can induce next generation sequencing negativity in patients with relapsed/refractory acute lymphoblastic leukemia, suggesting a "synergistic" relationship with hematopoietic cell transplant.
FDA Approvals in Myeloma and aTTP, Priority Review Designations in RCC and HNSCC, and More
PARP Inhibitors Hold Promise in mCRPC and Biallelic DNA Repair Gene Defects
Novel Agents Spark New Approaches for Triple-Negative Breast Cancer
Pembrolizumab/Cabozantinib Combo Is Well Tolerated, Shows Activity in Metastatic RCC
Pembrolizumab Shows Promising Activity in Non-Clear Cell RCC
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