Evolving Treatment Strategies in Chronic Lymphocytic Leukemia: Insights From ASH 2023

Chaitra S. Ujjani, MD, provides an overview of the frontline treatment landscape for CLL, highlighting key data and clinical factors to guide treatment selection.

Chaitra S. Ujjani, MD, examines extended follow-up data from the ALPINE trial, emphasizing noteworthy findings from the sensitivity and safety analyses recently presented at ASH 2023.

Chaitra S. Ujjani, MD examines extended follow-up data from the ALPINE trial, emphasizing noteworthy findings from the sensitivity and safety analyses recently presented at ASH 2023.

Oncology experts discuss findings from ELEVATE-RR and outline key considerations for combination therapy with acalabrutinib plus obinutuzumab.

Faculty offer expert guidance regarding treatment selection for patients with R/R CLL, highlighting parallels with frontline considerations.

Richard Furman, MD, outlines his strategy for addressing BTK inhibitor intolerance in CLL patients, underscoring the significance of BTK inhibitors in CLL treatment and advocating for transitioning to an alternative BTK inhibitor rather than completely discontinuing the class in cases of drug intolerance.

Faculty offer expert insights into emerging data on BTK inhibitor resistance in CLL, referencing earlier findings that indicate the potential existence of mutations before BTK inhibitor exposure and the process of clonal selection.