News|Videos|June 26, 2025

APPULSE-PNH: Oral Iptacopan Monotherapy Demonstrates Clinically Meaningful Hemoglobin (Hb) Increases in Patients (Pts) With Paroxysmal Nocturnal Hemoglobinuria (Pnh) and Hb ≥10 G/Dl Oo Anti-C5 Therapy

Author(s)Austin Kulasekararaj, MBBS, MD, MRCP, FRCPath

Austin Kulasekararaj, MBBS, MD, MRCP, FRCPath, presents results from the phase 3b APPULSE-PNH trial at the 2025 EHA Congress in Milan, Italy. The data demonstrate that, in patients with PNH and hemoglobin ≥10 g/dL who switched from anti-C5 therapy to iptacopan, iptacopan was superior in improving hemoglobin levels from baseline.

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APPULSE-PNH: Oral Iptacopan Monotherapy Demonstrates Clinically Meaningful Hemoglobin (Hb) Increases in Patients (Pts) With Paroxysmal Nocturnal Hemoglobinuria (Pnh) and Hb ≥10 G/Dl Oo Anti-C5 Therapy

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