Cases & Conversations™: Unmasking Epithelioid Sarcoma – Enhancing Early Diagnosis and Multidisciplinary Care

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Episode Description

In this podcast, experts Mark Agulnik, MD; Sandra D’Angelo, MD; Mrinal M. Gounder, MD; and Sujana Movva, MD; discuss the complexities of diagnosing epithelioid sarcoma (ES) in a timely manner and the importance of multidisciplinary care in treating this disease at all stages.

Learning Objectives

Upon successful completion of this activity, you should be better prepared to:

• Differentiate ES from other malignant and nonmalignant lesions by identifying its clinical presentation, histopathologic markers, and molecular features.
• Describe a multidisciplinary management approach for ES, integrating surgical oncology, pathology, radiation therapy, and medical oncology to optimize patient outcomes through coordinated care and individualized treatment planning.
• Identify when to refer patients with ES to specialized academic centers and clinical trials to expand access to novel therapies and research opportunities.

Acknowledgment of Educational Grant Support

This activity is supported by an educational grant from Ipsen.

Chair:

Mark Agulnik, MD

Professor of Clinical Medicine
Vice Chair for Faculty Development, Department of Medicine
Section Chief of Sarcomas & Melanoma
Division of Medical Oncology, Department of Medicine
Keck School of Medicine of the University of Southern California
Los Angeles, CA

Disclosures: Advisor, Consultant, Speaker, Honoraria Recipient:Aadi Bioscience, Boehringer Ingelheim, Daiichi Sankyo, Deciphera, SpringWorks

Faculty:

Sandra D’Angelo, MD

Associate Attending Physician
Memorial Sloan Kettering Cancer Center
New York, NY

Disclosures: Advisor, Consultant, Speaker, Honoraria Recipient: Aadi Bioscience, Adaptimmune, GI Innovation, GSK, Medendi, Nektar, Pfizer, Piper Sandler & Company, Rain Therapeutics, Ratio Therapeutics, Replimune; Grant/Research funding: Amgen, Bristol Myers Squibb, Deciphera, EMD Serono, Incyte, Merck, Nektar

Mrinal M. Gounder, MD

Medical Oncologist
Physician Ambassador to India and Asia
Bobst International Center
Memorial Sloan Kettering Cancer Center
New York, NY

Disclosures: Advisor, Consultant, Speaker, Honoraria Recipient: Ikena, Immunome, Kura Oncology, Orion, Parabilis, SpringWorks, Vivace; Grant/Research funding: Erasca, Ikena, Immunome, Kura Oncology, Orion, Parabilis, SpringWorks, Tango, Vivace

Sujana Movva, MD

Sarcoma Medical Oncologist
Memorial Sloan Kettering Cancer Center
New York, NY

Disclosures: Advisor, Consultant, Speaker, Honoraria Recipient: Deciphera; Grant/Research funding: Ascentage Pharma, Bristol Myers Squibb, Clovis, Hutchinson Medi-Pharma, Jazz, Pfizer, PharmaMar, TRACON

Faculty, Staff, and Planners’ Disclosures

In accordance with ACCME Guidelines, PER^® has identified and resolved all conflicts of interest for faculty, staff, and planners prior to the start of this activity by using a multistep process.

The staff of Physicians’ Education Resource^®, LLC, have no relevant financial relationships with ineligible companies.

This podcast, including the narration, was developed by PER^® editorial staff based on an online activity developed with these faculty. The narration was voiced by a PER staff member or by an AI tool.

To learn more about this topic, including information on the treatment of localized epithelioid sarcoma and subsequent lines of therapy for advanced disease, go to https://www.gotoper.com/cc25es-activity.

Release Date

February 24, 2026

Expiration Date

February 24, 2027

Off-Label Disclosure and Disclaimer

This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Learners are advised to consult prescribing information for any products discussed. The information provided in this accredited activity is for continuing education purposes only and is not meant to substitute for the independent clinical judgment of a health care professional relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER^® or any company that provided commercial support for this activity.