Jarushka Naidoo, MD, BCh, discusses the application of biomarker testing for use of checkpoint inhibitors in patients with cancer.
Jarushka Naidoo, MBBCh, assistant professor of oncology, John Hopkins University, discusses the application of biomarker testing for use of checkpoint inhibitors in patients with cancer.
Nadioo says that there are agents are now approved in 13 or more different cancer types; however, biomarker testing depends on the cancer type and at which stage the patient is at in their disease. PD-L1 testing via immunohistochemistry is one of the most extensive biomarker tests to be done.
Different companies utilize different antibodies to test for this particular biomarker, says Naidoo. For instance, different cell populations can be used to define PD-L1 activity, she concludes.