Experts highlight the most interesting and potentially paradigm-shifting head and neck cancer data to come out of the 2026 ASCO Annual Meeting.
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During the 2026 American Society of Clinical Oncology Annual Meeting, head and neck cancer experts highlighted the studies and investigational agents that hold the most promise for advancing treatment paradigms for head and neck squamous cell carcinoma (HNSCC), adenoid cystic carcinoma (ACC), and beyond.
Findings from cohort 1 of the phase 1b/2 OrigAMI-4 trial (NCT06385080) showed high, deep, and durable response rates among patients with recurrent or metastatic head and neck squamous cell carcinoma who received...
A post hoc analysis of SPEARHEAD-1 found that MAGE-A4 H-score was independently tied to response and progression-free survival, whereas baseline tumor burden was tied to overall survival.
The IL-12–expressing self-replicating mRNA STX-001 showed a favorable therapeutic window at 100 µg, with regression in both injected and non-injected lesions.
Most of the survival time accrued with RP1 plus nivolumab in the IGNYTE trial was spent in good health among patients with advanced melanoma after anti–PD-1 therapy.