Opinion|Videos|April 27, 2026

Long-Term Efficacy and Safety of Avutometinib + Defactinib in Patients With Recurrent Low-Grade Serous Ovarian Cancer: Results From ENGOT-ov60/GTG-UK/GOG-3052

Name: Long-Term Efficacy and Safety of Avutometinib + Defactinib in Patients With Recurrent Low-Grade Serous Ovarian Cancer: Results From ENGOT-ov60/GTG-UK/GOG-3052
Uploaded: 2026-04-27T15:20:00Z
Duration: 10 min 13 s
Description: Long-Term Efficacy and Safety of Avutometinib + Defactinib in Patients With Recurrent Low-Grade Serous Ovarian Cancer: Results From ENGOT-ov60/GTG-UK/GOG-3052

Author(s)Rachel N. Grisham, MD

This presentation evaluates the long-term safety and effectiveness of avutometinib plus defactinib in recurrent low-grade serous ovarian cancer, highlighting durable responses and manageable side effects, particularly in patients with KRAS mutations.

This presentation reviews the long-term safety and effectiveness of combining avutometinib and defactinib for treating recurrent low-grade serous ovarian cancer, particularly in patients with KRAS mutations. The findings show that the therapy can provide durable responses with manageable side effects, allowing some patients to remain on treatment for extended periods.

Overall, the results support this combination as a promising option with sustained clinical benefit and consistent safety outcomes.

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Long-Term Efficacy and Safety of Avutometinib + Defactinib in Patients With Recurrent Low-Grade Serous Ovarian Cancer: Results From ENGOT-ov60/GTG-UK/GOG-3052

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