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Opinion|Videos|June 26, 2026

Lorlatinib vs crizotinib as first-line treatment for advanced ALK+ non-small cell lung cancer: 7-year update from the phase 3 CROWN study

Author(s)Alice Shaw, MD, PhD

Seven-year data show lorlatinib keeps ALK+ lung cancer controlled, with durable brain protection, stable safety, and clues to early resistance.

This presentation details the long-term efficacy and safety outcomes from a Phase 3 study comparing lorlatinib to crizotinib for patients with advanced non-small cell lung cancer. It outlines how lorlatinib provides prolonged systemic and intracranial disease control, resisting common mutations while maintaining a consistent safety profile over several years. Additionally, the text incorporates genetic analysis to distinguish baseline biomarkers between early progressors and long-term treatment responders.

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