Opinion|Videos|January 21, 2026

Nivolumab plus ipilimumab vs. Lenvatinib or sorafebib as first-line treatment for unresectable hepatocellular carcinoma (HCC): 4-year follow-up of CheckMate 9DW

Name: Nivolumab plus ipilimumab vs. Lenvatinib or sorafebib as first-line treatment for unresectable hepatocellular carcinoma (HCC): 4-year follow-up of CheckMate 9DW
Uploaded: 2026-01-21T13:00:00Z
Duration: 5 min 55 s
Description: Nivolumab plus ipilimumab vs. Lenvatinib or sorafebib as first-line treatment for unresectable hepatocellular carcinoma (HCC): 4-year follow-up of CheckMate 9DW

Author(s)Peter Galle, MD

Four-year follow-up results from the Phase 3 CheckMate 9DW trial show that nivolumab plus ipilimumab continues to provide sustained overall survival and durable response benefits versus lenvatinib or sorafenib as first-line therapy for unresectable hepatocellular carcinoma. The combination demonstrated higher long-term survival rates and a higher complete response rate, with no new safety signals reported.

Updated data from the global Phase 3 CheckMate 9DW trial reinforce nivolumab plus ipilimumab as a first-line standard of care for unresectable hepatocellular carcinoma. At a median follow-up of over four years, the regimen showed sustained overall survival benefit, higher 24-, 36-, and 48-month survival rates, and clinically meaningful improvements in objective response and complete response rates versus lenvatinib or sorafenib. The safety profile remained manageable with no new safety signals identified.

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Nivolumab plus ipilimumab vs. Lenvatinib or sorafebib as first-line treatment for unresectable hepatocellular carcinoma (HCC): 4-year follow-up of CheckMate 9DW

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