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Opinion|Videos|April 30, 2026

Taletrectinib in TKI-Pretreated Patients With ROS1+ Non-Small Cell Lung Cancer: Updated Data From TRUST-I and TRUST-II

Author(s)Lyudmila Bazhenova, MD

Taletrectinib is a next-generation targeted therapy for ROS1-positive non-small cell lung cancer that has shown strong and durable tumor responses in both treatment-naïve and previously treated patients. It demonstrates meaningful activity in the brain and maintains a manageable safety profile with mostly mild side effects. Overall, the findings support its use as an effective and well-tolerated treatment option in this patient population.

Taletrectinib is a next-generation targeted therapy for ROS1-positive non-small cell lung cancer that has shown strong and durable tumor responses in both treatment-naïve and previously treated patients. It demonstrates meaningful activity in the brain and maintains a manageable safety profile with mostly mild side effects. Overall, the findings support its use as an effective and well-tolerated treatment option in this patient population.

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