Translating Evidence to Clinical Practice to Improve Outcomes in Patients with Small Cell Lung Cancer
In a recent OncLive® Scientific Interchange moderated by David R. Gandara, MD, experts discussed the prevalence and pathobiology of SCLC cases in their practices; the role of surgery, radiation, prophylactic cranial irradiation (PCI), and systemic therapy in LS-SCLC; and optimal systemic approaches for ES-SCLC in the first-line and relapsed settings.
The first MRD data from the phase 3 EXCALIBER-RRMM trial support iberdomide-based triplet therapy as early as first relapse, with PFS follow-up ongoing.
After nearly 7 years of follow-up, daratumumab added to VRd continued to improve PFS, PFS2, and sustained MRD negativity in transplant-eligible myeloma.
Daiichi Sankyo and Merck withdrew the I-DXd BLA in ES-SCLC after FDA discussions found phase 2 IDeate-Lung01 data insufficient for accelerated approval.
Monthly etentamig significantly improved response and PFS over standard available therapies in the phase 3 CERVINO trial, with low rates of high-grade CRS.