Many patients with BRAF-altered pediatric low-grade glioma stayed off therapy after planned tovorafenib cessation in the 4-year FIREFLY-1 update.
Opinion|Videos|April 13, 2026
Updated Efficacy and Safety Results of the Bruton Tyrosine Kinase Degrader BGB-16673 in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma From the Ongoing Phase 1 CaDAnCe-101 Study
Author(s)Nicole Lamanna, MD
UCSF real-world CLL study pits zanubrutinib vs acalabrutinib, showing fewer next treatments and AI-extracted adverse events.
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This presentation reports updated results on a novel BTK degrader therapy for patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma. The treatment showed strong anti-tumor activity across different patient subgroups, including those with prior therapies and resistance mutations, while maintaining a manageable safety profile without new concerns about toxicities. Overall, the findings suggest this therapy is a promising option that continues to be evaluated in ongoing clinical studies.
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