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EU Panel Recommends Pembrolizumab/Chemo Combo in Squamous NSCLC

Gina Columbus @ginacolumbusonc
Published: Monday, Feb 04, 2019

Dr. Roy Baynes

Roy Baynes, MD, PhD
The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion for first-line treatment with pembrolizumab (Keytruda) in combination with carboplatin and either paclitaxel or nab-paclitaxel (Abraxane) in patients with metastatic squamous non–small cell lung cancer (NSCLC).1

The decision is based on findings from the phase III KEYNOTE-407 trial, in which patients were enrolled regardless of PD-L1 expression status. Results showed that there was a significant improvement in progression-free and overall survival (OS) for those who received the combination versus chemotherapy alone.2,3

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