Mazyar Shadman, MD, MPH
Now that the CD19-targeted CAR T-cell therapies axicabtagene ciloleucel (axi-cel; Yescarta) and tisagenlecleucel (Kymriah) have shown durable responses in the relapsed/refractory settings of non-Hodgkin lymphoma, researchers are hopeful that earlier exposure may heighten the curative potential of the modality, explained Mazyar Shadman, MD, MPH.
Both constructs are indicated for patients with relapsed/refractory large B-cell lymphoma who have received ≥2 lines of systemic treatment, but a handful of trials are investigating axi-cel and tisagenlecleucel in earlier settings. One such trial is the single-center, phase II ZUMA-12 trial (NCT03761056). In the study, patients with high-risk large B-cell lymphoma will receive a single infusion of axi-cel at a target dose of 2 × 106
CAR T cells/kg.
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