KD025 Hits High Response Rate in Chronic GVHD

Treatment with the selective ROCK2 inhibitor KD025 led to statistically significant overall response rates (ORRs) in patients with chronic graft-versus-host disease (cGVHD) who have received ≥2 prior lines of systemic therapy, meeting the primary endpoint at an interim analysis of the phase II ROCKstar trial (KD025-213; NCT03640481).1

Cytokines (IL-21, IL-17) regulated by the ROCK2 signaling pathway play an integral role in the pathogenesis of cGVHD. Clinical research has demonstrated that inhibiting the ROCK2 pathway reduces the pathogenesis of cGVHD.

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