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Nivolumab/RT Combo Misses OS Endpoint in Newly Diagnosed Glioblastoma Trial

Gina Columbus @ginacolumbusonc
Published: Thursday, May 09, 2019

Fouad Namouni, MD

Fouad Namouni, MD
The combination of nivolumab (Opdivo) plus radiation therapy compared with temozolomide did not improve overall survival (OS) in patients with newly diagnosed O6-methylguanine-DNA methyltransferase (MGMT)-unmethylated glioblastoma multiforme (GBM), missing the coprimary endpoint of the phase III CheckMate-498 trial.1

The ongoing phase III CheckMate-548 trial (NCT02667587) is evaluating nivolumab in combination with radiation therapy and temozolomide in patients with newly diagnosed MGMT-methylated GBM.

References

  1. Bristol-Myers Squibb Announces Phase 3 CheckMate-498 Study Did Not Meet Primary Endpoint of Overall Survival with Opdivo (nivolumab) Plus Radiation in Patients with Newly Diagnosed MGMT-Unmethylated Glioblastoma Multiforme. Bristol-Myers Squibb. Published May 9, 2019. https://bit.ly/2V9ceag. Accessed May 9, 2019.
  2. Reardon DA, Omuro A Brandes AA, et al. Randomized phase 3 study evaluating the efficacy and safety of nivolumab vs bevacizumab in patients with recurrent glioblastoma: CheckMate 143. Neuro-Oncol. 2017;19(3):iii21. doi: 10.1093/neuonc/nox036.071.

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