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Stephen Liu, MD, Georgetown Lombardi Comprehensive Cancer Center

Articles by Stephen Liu, MD, Georgetown Lombardi Comprehensive Cancer Center

Future Directions in Treatment of Small Cell Lung Cancer

ByHossein Borghaei, DO, MS, Fox Chase Cancer Center,Anne Chiang, MD, PhD, Yale Cancer Center,Wade Iams, MD, Vanderbilt University Medical Center,Stephen Liu, MD, Georgetown Lombardi Comprehensive Cancer Center,Vivek Subbiah, MD, MD Anderson Cancer Center

Panelists conclude their discussion by commenting on areas of unmet need and sharing personal perspectives on factors that may change clinical practice for SCLC in the future.

Emerging Treatments in SCLC: Triplets + Limited-Stage Disease

ByHossein Borghaei, DO, MS, Fox Chase Cancer Center,Anne Chiang, MD, PhD, Yale Cancer Center,Wade Iams, MD, Vanderbilt University Medical Center,Stephen Liu, MD, Georgetown Lombardi Comprehensive Cancer Center,Vivek Subbiah, MD, MD Anderson Cancer Center

Anne Chiang, MD, PhD, reviews the study design of 2 clinical trials, adding a third agent to the standard-of-care regimen of chemotherapy plus I/O; Stephen Liu, MD, discusses clinical trials in limited-stage disease.

Emerging Treatments in SCLC: Bispecific Antibodies

ByHossein Borghaei, DO, Fox Chase Cancer Center,Anne Chiang, MD, PhD, Yale Cancer Center,Wade Iams, MD, Vanderbilt University Medical Center,Stephen Liu, MD, Georgetown Lombardi Comprehensive Cancer Center,Vivek Subbiah, MD, MD Anderson Cancer Center

Expert panelists weigh in on emerging data from recent presentations on small cell lung cancer, including novel immunotherapy approaches such as bispecific antibodies targeting DLL3 or therapies targeting TIGIT.

SCLC: Second-Line Options and Supportive Care

ByHossein Borghaei, DO, MS, Fox Chase Center at Temple Health,Anne Chiang, MD, PhD, Yale Cancer Center,Wade Iams, MD, Vanderbilt University Medical Center,Stephen Liu, MD, Georgetown Lombardi Comprehensive Cancer Center,Vivek Subbiah, MD, MD Anderson Cancer Center

Key opinion leaders in thoracic oncology provide insights into second-line treatment for patients with relapsed/refractory small cell lung cancer and comment on the role of trilaciclib in managing cisplatin-associated neutropenia.

Single Agent I/O Therapy for Relapsed/Refractory

ByHossein Borghaei, DO, MS, Fox Chase Center at Temple Health,Anne Chiang, MD, PhD, Yale Cancer Center,Wade Iams, MD, Vanderbilt University Medical Center,Stephen Liu, MD, Georgetown Lombardi Comprehensive Cancer Center,Vivek Subbiah, MD, MD Anderson Cancer Center

Lung cancer expert Anne Chiang, MD, PhD, considers the recent withdrawal of FDA-accelerated approval for nivolumab and pembrolizumab for patients with relapsed extensive-stage small cell lung cancer.

Treatment Considerations: Chemotherapy + IO in ES SCLC

ByHossein Borghaei, DO, MS, Fox Chase Cancer Center,Anne Chiang, MD, PhD, Yale Cancer Center,Wade Iams, MD, Vanderbilt University Medical Center,Stephen Liu, MD, Georgetown Lombardi Comprehensive Cancer Center,Vivek Subbiah, MD, MD Anderson Cancer Center

Panelists reflect on key points from recent studies in ES SCLC by discussing patients for whom immunotherapy may be appropriate, examining the role of adding CTLA4 inhibition to a PD-L1 inhibitor, and reviewing factors to consider when deciding between cisplatin or carboplatin.

First-Line Therapy in ES SCLS: KEYNOTE-604

ByHossein Borghaei, DO, Fox Chase Cancer Center,Anne Chiang, MD, PhD, Yale Cancer Center,Wade Iams, MD, Vanderbilt University Medical Center,Stephen Liu, MD, Georgetown Lombardi Comprehensive Cancer Center,Vivek Subbiah, MD, MD Anderson Cancer Center

Key opinion leader in lung cancer, Vivek Subbiah, MD, examines the phase 3 KEYNOTE-604 trial of platinum-based chemotherapy + pembrolizumab and considers whether the data support findings from other trials of chemotherapy + IO combination approaches.

First-Line Therapy in ES SCLC: CASPIAN

ByHossein Borghaei, DO, MS, Fox Chase Cancer Center,Anne Chiang, MD, PhD, Yale Cancer Center,Wade Iams, MD, Vanderbilt University Medical Center,Stephen Liu, MD, Georgetown Lombardi Comprehensive Cancer Center,Vivek Subbiah, MD, MD Anderson Cancer Center

Thoracic oncologist, Anne Chiang, MD, PhD, reviews the trial design and results of the CASPIAN trial and emphasizes implications for long-term benefit of combining platinum chemotherapy with durvalumab.

First-Line Therapy in ES SCLC: IMpower133

ByHossein Borghaei, DO, MS, Fox Chase Cancer Center,Stephen Liu, MD, Georgetown Lombardi Comprehensive Cancer Center,Vivek Subbiah, MD, MD Anderson Cancer Center,Anne Chiang, MD, PhD, Yale Cancer Center,Wade Iams, MD, Vanderbilt University Medical Center

Stephen Liu, MD guides a discussion on recent updates on IO+chemotherapy combinations in extensive-stage small cell lung cancer by reviewing data from the phase 3 IMpower133 l trial of carboplatin/etoposide/atezolizumab.

WCLC Updates in Neoadjuvant Therapy for NSCLC

ByStephen Liu, MD, Georgetown Lombardi Comprehensive Cancer Center,Sarah Goldberg, MD, MPH, Yale School of Medicine,Benjamin Levy, MD, Johns Hopkins Sidney Kimmel Cancer Center,Heather A. Wakelee, MD, Stanford University Medical Center

Experts in thoracic oncology discuss the role of single-agent immunotherapy as neoadjuvant therapy and comment on the viability of MPR [major pathologic response] as a surrogate endpoint for non–small cell lung cancer (NSCLC).

WCLC Updates in KRAS and Rare EGFR-Mutated NSCLC

ByStephen Liu, MD, Georgetown Lombardi Comprehensive Cancer Center,Sarah Goldberg, MD, MPH, Yale School of Medicine,Benjamin Levy, MD, Johns Hopkins Sidney Kimmel Cancer Center,Heather A. Wakelee, MD, Stanford University Medical Center

Experts in thoracic oncology review data presented at the IASLC 2020 World Conference on Lung Cancer (WCLC) and discuss safety and efficacy of targeted agents for patients with KRAS- or EGFR-mutated non–small cell lung cancer (NSCLC).

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