Dr. Hodi on Long-Term Survival Data for Nivolumab in Melanoma

F. Stephen Hodi, MD
Published: Sunday, Apr 17, 2016



F. Stephen Hodi, MD, director of the Melanoma Center at Dana-Farber Cancer Institute, and investigator at the Ludwig Center at Harvard, discusses the results of a 5-year follow-up analysis of survival outcomes of patients with advanced melanoma who were treated with single-agent nivolumab (Opdivo).

The phase I study of nivolumab, which was conducted in 2008, examined the survival outcomes of 107 heavily pretreated patients treated with nivolumab. With the long-term follow-up, Hodi noted there were no new safety signals and no treatment-related deaths. Moreover, 34% of patients remained alive at the 5-year follow-up.

This study's results show that anti–PD-1 therapy can give long-term benefits to patients with advanced melanoma. Hodi is hopeful that this benefit will translate to patients treated with nivolumab with other cancers, as well. 

<<< View more from the 2016 AACR Annual Meeting



F. Stephen Hodi, MD, director of the Melanoma Center at Dana-Farber Cancer Institute, and investigator at the Ludwig Center at Harvard, discusses the results of a 5-year follow-up analysis of survival outcomes of patients with advanced melanoma who were treated with single-agent nivolumab (Opdivo).

The phase I study of nivolumab, which was conducted in 2008, examined the survival outcomes of 107 heavily pretreated patients treated with nivolumab. With the long-term follow-up, Hodi noted there were no new safety signals and no treatment-related deaths. Moreover, 34% of patients remained alive at the 5-year follow-up.

This study's results show that anti–PD-1 therapy can give long-term benefits to patients with advanced melanoma. Hodi is hopeful that this benefit will translate to patients treated with nivolumab with other cancers, as well. 

<<< View more from the 2016 AACR Annual Meeting




View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Medical Crossfire®: Evolving Roles for Targeted Melanoma Therapies: Assessing Rapid Progress in the Field and Looking Toward Future CombinationsFeb 28, 20191.5
Advances in™ Melanoma: Exploring BRAF/MEK in Adjuvant and Neoadjuvant SettingsSep 28, 20191.5
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