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Oncology Conference Articles
Novel Bladder Cancer Strategies Target PD-1/PD-L1 and VEGF Pathways
Emerging agents targeting the PD1/PD-L1 pathway and the process of angiogenesis are shaping up to be promising options to break a 30-year drought in new therapies for patients with progressive metastatic urothelial bladder cancer.
Gomella Discusses Radium-223 Impact in mCRPC
Leonard Gomella, MD, discusses the optimal patient population to receive radium-223 for prostate cancer and how oncologists should best use it.
Questions Loom Over Androgen-Targeting Strategies in Metastatic Prostate Cancer
Targeting androgen receptor signaling with recently approved agents has improved outcomes for men with metastatic castration-resistant prostate cancer but significant questions linger about how to tackle resistance to the therapies.
Oral HDAC Inhibitor Improves Antitumor Activity of IL-2 in mRCC
A selective class I oral histone deactylase inhibitor may increase the antitumor effect of high- dose interleukin-2 in renal cell carcinoma.
Nivolumab's Survival Benefit Sustained Across RCC Subgroups
Nivolumabâ€™s second-line survival benefit in renal cell carcinoma was consistent across subgroups categorized by patient risk status, prior treatment, and degree of metastases, according to an update of the phase III CheckMate-025 trial.
Hypofractionated Radiotherapy May Be New Standard of Care in Prostate Cancer
Hypofractionated radiotherapy demonstrated similar toxicity and was noninferior to standard radiation therapy for preventing PSA increases or disease recurrences for men with intermediate-risk prostate cancer.
Atezolizumab Update Affirms Activity in Bladder Cancer
Second-line treatment with atezolizumab (MPDL3280A) led to durable responses in patients with locally advanced or metastatic urothelial carcinoma.
Combo of Celecoxib and Zoledronic Acid Improves Survival in Metastatic Prostate Cancer
Adding celecoxib and zoledronic acid to standard treatment extended survival in men with metastatic prostate cancer commencing first-line hormone therapy, according to updated data from the STAMPEDE trial.
First Checkpoint/Chemo Combo Study for Urothelial Cancer Falls Short
The addition of the CTLA-4 inhibitor ipilimumab to cisplatin and gemcitabine did not significantly improve overall survival for patients with metastatic urothelial cancer.
Avelumab Spurs Responses in Refractory Metastatic Urothelial Cancer
The investigational anti-PD-L1 antibody avelumab demonstrated antitumor activity with an acceptable safety profile in a phase Ib trial of patients with metastatic urothelial cancer refractory to standard therapy.
Docetaxel First Choice After Abiraterone in 50% of Patients with mCRPC
A post hoc analysis of the COU-AA-302 clinical trial suggests that docetaxel has antitumor activity as first subsequent therapy following disease progression with abiraterone acetate in men with chemotherapy-naÃ¯ve, metastatic castration-resistant prostate cancer.
Can Aspirin Avert Lethal Prostate Cancer? Long-term Study Suggests a Possible Role
Aspirinâ€™s benefits may now extend to reducing the risk of deadly prostate cancer, according to the results of an observational study which found that previously undiagnosed men who took regular aspirin had a 24% lower risk of developing a lethal form of the disease.
Liquid Biopsy Paves Way for Personalized Selection Tool in Prostate Cancer
The non-invasive liquid biopsy, if validated, could lead to the development of a personalized selection tool in men with advanced prostate cancer.
Cabozantinib Improves PFS Across High-Risk RCC Subgroups
Cabozantinib significantly improved progression-free survival versus everolimus in patients with renal cell carcinoma regardless of the degree of metastases, type or number of prior treatments, or patient risk status.
FDA Approvals in Myeloma and aTTP, Priority Review Designations in RCC and HNSCC, and More
Novel Agents Spark New Approaches for Triple-Negative Breast Cancer
Hereditary Prostate Cancer—What Urologists Should Know
FDA Grants Pembrolizumab/Axitinib Combo Priority Review for Frontline RCC
Targeting BCL-2 in Hematologic Malignancies
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