My Treatment Approach: Graft vs Host Disease

Nelson J. Chao, MD, MBA, presents the patient profile of a 60-year-old man with chronic myeloid leukemia and graft-versus-host disease (GVHD) and shares his initial impressions.

Dr Nelson J. Chao reviews how chronic graft-versus-host disease is diagnosed and staged, and the importance of multidisciplinary team communication.

Nelson J. Chao, MD, MBA, explains the frontline treatment options for chronic GVHD, and when to consider restarting an immunosuppressive regimen.

Dr Nelson J. Chao presents the patient profile of a 67-year-old woman with chronic graft-versus-host disease after a bone marrow donation from a multiparous female.

Nelson J. Chao, MD, MBA, details some novel agents being developed for the systemic treatment of GVHD, particularly chronic GVHD.

Dr Nelson J. Chao reviews treatment sequencing and speculates on the future of the GVHD treatment landscape.

Pashna Munshi, MD, presents the patient profile of a 44-year-old woman with acute myeloid leukemia diagnosed with grade 2 skin acute GVHD, and shares her initial impressions and what she might have done differently.

Dr Pashna Munshi describes for what myeloid malignancies allogeneic transplantation is indicated, and its curative potential.

Pashna Munshi, MD, details how age and risk factors into her choice of conditioning regimen for patients with GVHD receiving allogeneic transplant.

Dr Pashna Munshi explains the currently available options for GVHD prophylaxis and which regimens she utilizes the most in her clinical practice.

Pashna Munshi, MD, reviews the differences between acute and chronic GVHD.

Pashna Munshi, MD, discusses how acute GVHD is staged and graded, and the common frontline treatment options.

Closing her discussion, Dr Pashna Munshi reviews recent data on the available treatment options for patients with steroid-refractory acute GVHD.