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The TOP Study and Beyond — TP53 as a Treatment-Selection Biomarker in First-Line EGFR-Mutant NSCLC

2 experts are featured in this series.

EP. 1: Introduction and TP53 Background in EGFR-Mutant NSCLC

ByEstelamari Rodriguez, MD, MPH,Coral Olazagasti, MD
June 26th 2026

TOP study prospectively shows TP53-mutant EGFR lung cancer gains from first-line combination therapy, reshaping choices amid FLAURA2 and MARIPOSA.

2 experts are featured in this series.

EP. 2: TOP Study Design and Results

ByEstelamari Rodriguez, MD, MPH,Coral Olazagasti, MD
June 26th 2026

Experts unpack TOP trial data on TP53 co-mutations, guiding first-line EGFR lung cancer choices between osimertinib alone or with chemo.

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