Dr. Peter Beitsch on Pertuzumab in Luminal Subtype Breast Cancer

Peter Beitsch, MD
Published: Monday, Jan 18, 2016



Peter Beitsch, MD, president of The American Society of Breast Surgeons, Dallas Surgical Group, discusses the impact of pertuzumab on patients with luminal subtype breast cancer.

Triple-positive patients, who are ER-positive, PR-positive, and HER2-neu positive, respond less to chemotherapy plus trastuzumab than those who are ER-negative. The reason for this has never been well understood, says Beitsch.

Based on the Neoadjuvant Breast Registry - Symphony Trial (NBRST), triple-positive patients were broken into two groups—HER2-neu driven and luminal subtype. It was determined that there was almost a pathological complete response (pCR) with chemotherapy plus trastuzumab in the luminal subtype, while those who were HER2-neu driven saw a response, says Beitsch.

Over the course of the study, pertuzumab was added as part of the standard of care to chemotherapy plus trastuzumab. This increased pCR rates in the luminal subtype group.

SELECTED
LANGUAGE


Peter Beitsch, MD, president of The American Society of Breast Surgeons, Dallas Surgical Group, discusses the impact of pertuzumab on patients with luminal subtype breast cancer.

Triple-positive patients, who are ER-positive, PR-positive, and HER2-neu positive, respond less to chemotherapy plus trastuzumab than those who are ER-negative. The reason for this has never been well understood, says Beitsch.

Based on the Neoadjuvant Breast Registry - Symphony Trial (NBRST), triple-positive patients were broken into two groups—HER2-neu driven and luminal subtype. It was determined that there was almost a pathological complete response (pCR) with chemotherapy plus trastuzumab in the luminal subtype, while those who were HER2-neu driven saw a response, says Beitsch.

Over the course of the study, pertuzumab was added as part of the standard of care to chemotherapy plus trastuzumab. This increased pCR rates in the luminal subtype group.


View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
35th Annual Chemotherapy Foundation Symposium: Innovative Cancer Therapy for Tomorrow® Clinical Vignette SeriesJan 31, 20192.0
Community Practice Connections™: How Do We Leverage PARP Inhibition Strategies in the Contemporary Treatment of Breast Cancer?May 31, 20191.5
Publication Bottom Border
Border Publication
x