OncLive TV

Lena Specht, MD, DMSc, discusses data for mogamulizumab in Danish patients with mycosis fungoides or Sezary syndrome and their effect on clinical practice.

Robert Stuver, MD, discusses how to approach treatment for primary cutaneous peripheral T-cell lymphoma and which factors to consider.

H. Miles Prince, MD, MBBS discusses data for mogamulizumab from MAVORIC vs real-world vorinostat in R/R MF and SS.

From CD94 antibodies to TNF-α and EZH2, Neha Mehta-Shah, MD, MSCI, explains how a wave of newly mapped targets is reshaping cutaneous T-cell lymphoma.

Neha Mehta-Shah, MD, MSCI explains how rational combinations to overcome CTCL treatment resistance keep running into added toxicity.

Julia Scarisbrick, MD, explains how better recognition of mogamulizumab-associated rash is moving the drug earlier in the mycosis fungoides and Sézary treatment course.

Julia Scarisbrick reviews real-world data showing mogamulizumab eased itch, pain, flaking, sleep, and fatigue in MF and Sézary syndrome as early as 4 weeks.

Christiane Querfeld, MD, PhD, discusses why early symptom relief drives adherence in mycosis fungoides and Sézary syndrome, and reframing MAR as an immune flare helps patients stay the course.

Christiane Querfeld, MD, PhD, discusses how targeted sequencing data show Sézary syndrome responds to mogamulizumab better than mycosis fungoides.

Jan P. Nicolay, MD, PhD, explains how early single-cell data suggest mogamulizumab resistance switches on anti-apoptotic survival proteins.

Jan P. Nicolay, MD, PhD, explains why some patients stop responding to mogamulizumab comes down to the tumor shedding its target and new survival mechanisms the cell switches on.

Two cutaneous lymphoma experts — Michael Girardi, MD, and Joan Guitart, MD — stake out opposite answers to whether SPTCL is truly a lymphoma.

Robert Stein, MBBS, PhD, discusses data from the OPTIMA trial in ER+, HER2– early breast cancer.

Alicia Morgans, MD, MPH, discusses the clinical significance of data from the phase 2 ARACOG trial in prostate cancer.

A rare cutaneous lymphoma that can mimic lupus and melt away on steroids still belongs in the malignancy category, based on how it behaves off treatment.

In part 2, the debaters map the trial that could settle the question and agree that, for now, individualized care and closer monitoring should guide high-risk early MF.

Stopping mogamulizumab after a strong response — then resuming it at relapse — emerged as a viable strategy for select patients with Sézary syndrome.

In the beginning of a two-part debate, two experts agree the evidence to treat poor-prognosis early MF differently from the onset isn’t here yet.

A planned mogamulizumab break emerged as best suited to older patients not bound for transplant, pending prospective confirmation.

Alicia Morgans, MD, MPH, discusses data on the cognitive effects of enzalutamide vs darolutamide in prostate cancer from the ARACOG trial.

Alicia Morgans, MD, MPH, discusses the background of the ARACOG trial in prostate cancer.

Sara M. Tolaney, MD, MPH, highlights the FDA approval of sacituzumab govitecan plus pembrolizumab for first-line TNBC management.

Claire Roddie, PhD, FRCPath, MBChB, MRCP, discusses outcomes with obe-cel by disease burden at screening/lymphodepletion in B-cell acute lymphoblastic leukemia.

Michael A. Postow, MD, discusses the current evidence gaps surrounding the management of irAEs in melanoma in the long term.

David O’Malley, MD, discusses how ADCs have redefined the treatment paradigm in platinum-resistant ovarian cancer.

Brian Myre, MD, discusses early data with SYNC-T SV-102 in advanced/metastatic castration-resistant prostate cancer.

Mazyar Shadman, MD, MPH, discusses data from the phase 1/1b BGB-11417-101 trial of sonrotoclax plus zanubrutinib in frontline CLL/SLL.

Michael A. Postow, MD, discusses the importance of multidisciplinary coordination following immune checkpoint inhibitor therapy completion for patients with melanoma.

Michael A. Postow, MD, discusses the significance of understanding how to identify late-onset irAEs and underlying comorbidities unrelated to treatment in melanoma.

Sara M. Tolaney, MD, MPH, discusses an analysis of depth of response in HER2-positive advanced/metastatic breast cancer treated with T-DXd plus pertuzumab.