Recent Advances in the Treatment of Chronic GVHD: ASH 2024

Panelists discuss how graft-vs-host disease (GVHD) is a complex immune-mediated condition, highlighting the differences between acute and chronic GVHD, the associated risk factors, prognosis, and the impact of increased cyclophosphamide use on the clinical presentation of the disease.

Panelists discuss how early diagnosis and intervention are critical in improving outcomes for patients with GvHDGVHD patients, sharing strategies for identifying and treating GvHDGVHD in its earliest stages, and providing insights into diagnostic approaches used in clinical practice.

Panelists discuss how the first-line treatment for chronic GVHD typically involves steroids, explaining the rationale for their use, their effects on the organs involved, and how they help manage the immune response in patients with GVHD.

Panelists discuss how to monitor patients with chronic GvHDGVHD on steroids as first-line treatment, emphasizing the importance of early recognition and management of skin rash in patients with GvHDGVHD patients, and highlighting the critical role of prompt intervention in preventing complications.

Panelists discuss available treatment options for patients with chronic graft-vs-host disease (cGVHD) after steroid use, including factors that influence therapy selection, such as mechanism of action (MOA) and the mode of drug administration (oral vs intravenous [IV]).

Panelists discuss key updates in the NCCN guidelines for the management of chronic graft-vs-host disease (cGVHD) and how these updates have influenced their clinical approach to treatment and patient care.

Panelists review the data supporting the use of currently FDA-approved therapies for the management of chronic graft-versusvs-host disease (cGVHD), focusing on efficacy, safety, and real-world outcomes in clinical practice.

Panelists discuss the key challenges and limitations of existing therapies for graft-versusvs-host disease (GVHD), and explore current approaches to sequencing treatments, focusing on how to optimize patient outcomes while managing therapy-related risks.

Panelists discuss the role of combination therapies in the management of graft-vs-host disease (GVHD), exploring the potential benefits and challenges of using multiple agents concurrently to improve treatment outcomes and manage complications.