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Opinion|Videos|July 22, 2024

AE Management for Combination Regimens in Advanced RCC

Author(s)Martin H. Voss, MD, Moshe Ornstein, MD

The key opinion leaders engage in discussion on dose reduction and treatment duration rates in the context of the CLEAR study, which investigated lenvatinib plus pembrolizumab in advanced renal cell carcinoma (RCC), addressing important aspects such as optimal starting doses, the potential for reverting to higher doses, and the implications of these strategies on overall treatment efficacy and patient outcomes.

Episodes in this series

2 KOLs are featured in this series

EP. 1 Evolving Treatment Standards in Non-Clear Cell RCC

2 KOLs are featured in this series

EP. 2 Extended Follow Up of KEYNOTE-B61

2 KOLs are featured in this series

EP. 3 Ongoing Clinical Trials in the front-line setting of advanced non-clear cell RCC

2 KOLs are featured in this series

EP. 4 STELLAR 304: Zanzalintinib plus nivolumab in non-clear cell RCC

2 KOLs are featured in this series

EP. 5 Case Presentation: 61-year-old male Renal Cell Carcinoma

2 KOLs are featured in this series

EP. 6 Use of Combination Regimens in Frontline RCC

2 KOLs are featured in this series

EP. 7 Treatment Decision Making in first-line combinations for advanced RCC

2 KOLs are featured in this series

EP. 8 AE Management for Combination Regimens in Advanced RCC

2 KOLs are featured in this series

EP. 9 AE Management for Combination Regimens in Advanced RCC

2 KOLs are featured in this series

EP. 10 Optimizing Treatment in Advanced RCC

1 KOL is featured in this series.

EP. 11 Dr Albiges Discusses a Non-Clear Cell RCC Patient Profile

1 KOL is featured in this series.

EP. 12 Updates in the Treatment Approach for Non-clear cell RCC

1 KOL is featured in this series.

EP. 13 Dr Albiges Reviews Long term follow up data from KEYNOTE-B61

1 KOL is featured in this series.

EP. 14 Emerging Therapies in the Front-line Setting of Advanced non-clear cell RCC

1 KOL is featured in this series.

EP. 15 Biomarker-driven combination treatment approach in non-clear cell RCC (Met-driven)

1 KOL is featured in this series.

EP. 16 Summary and Forward Looking for RCC

Please comment on dose reduction and treatment duration rates in the CLEAR study and real-world experience. (Motzer JCO 2024).
1. What are the typical starting doses for lenvatinib and pembrolizumab in your practice?
2. What is your approach to dose reductions and reverting to higher doses in your practice?
What are some commonly observed adverse events with IO-TKI regimens?
1. What strategies do you implement to mitigate and monitor for common side effects?
2. What interventions help promote early AE detection and proactive mitigation?

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