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Opinion|Videos|October 14, 2024

ARPI-Based Combination Regimens – PEACE-3 (Radium-223 and enzalutamide)

Author(s)Neal D. Shore, MD, Petros Grivas MD, PhD

Panelists discuss how the PEACE-3 trial explores the efficacy of combining radium-223 with enzalutamide in advanced prostate cancer, highlighting its potential to enhance therapeutic outcomes and survival rates.

Episodes in this series

EP. 1 Treatment Landscape and Sequencing of Therapies

EP. 1 Treatment Landscape and Sequencing of Therapies

EP. 2 Treatment Timelines Related to Disease State and Use of Monotherapy

EP. 2 Treatment Timelines Related to Disease State and Use of Monotherapy

EP. 3 Genetic Testing – Germline

EP. 3 Genetic Testing – Germline

EP. 4 Recent Data on ARPI-Based Combination Regimens

EP. 4 Recent Data on ARPI-Based Combination Regimens

EP. 5 Genetic Testing – Somatic

EP. 5 Genetic Testing – Somatic

EP. 6 ARPI-Based Combination Regimens – PEACE-3 (Radium-223 and enzalutamide)

EP. 6 ARPI-Based Combination Regimens – PEACE-3 (Radium-223 and enzalutamide)

EP. 7 Use of Bone Protection Agents

EP. 7 Use of Bone Protection Agents

EP. 8 ARPI-Based Combination Regimens – ARANOTE (Darolutamide and ADT)

EP. 8 ARPI-Based Combination Regimens – ARANOTE (Darolutamide and ADT)

EP. 9 ARPI-Based Combination Regimens – CONTACT-02 (Cabozantinib plus atezolizumab)

EP. 9 ARPI-Based Combination Regimens – CONTACT-02 (Cabozantinib plus atezolizumab)

EP. 10 ARPI-Based Combination Regimens – SPLASH (177 Lu-PNT-2002)

EP. 10 ARPI-Based Combination Regimens – SPLASH (177 Lu-PNT-2002)

EP. 11 Key Takeaways and Looking Ahead

EP. 11 Key Takeaways and Looking Ahead

What are your thoughts about this new combination of enzalutamide and radium-223 as a first-line therapy in metastatic castration-resistant prostate cancer?

Is PEACE III a game changer? Does it change the guidelines?

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