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Preclinical cytotoxicity was demonstrated with anti-CD38-CAR-gamma-delta T cells in multiple myeloma.

Anti-CD38-CAR-γδ T Cells Show Preclinical Cytotoxicity in Myeloma

MT-8421, a novel engineered toxin body targeting CTLA-4, was not associated with grade 4 or 5 toxicities in patients with select advanced solid tumors.

MT-8421 Displays Acceptable Safety Profile in First-in-Human Trial for Advanced Solid Tumors

SAR444200-mediated targeting of GPC3-expressing solid tumors was safe and showed early signs of antitumor activity in a phase 1/2 study. 

SAR444200 Demonstrates Safety, Signals of Clinical Activity in Advanced GPC3+ HCC, Other Solid Tumors

The feasibility and safety of treatment with SAR443216 support the further investigation of this agent in patients with advanced HER2-positive tumors.

SAR443216 Engages HER2 With Manageable Toxicity in Advanced HER2+ Solid Tumors

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Patients with relapsed/refractory MCL who opted for elective treatment interruptions from venetoclax/ibrutinib experienced durable responses. 

7-Year Data Show Feasibility of Elective Treatment Interruption of Venetoclax/Ibrutinib in R/R MCL 

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as well as news and conference updates for OncLive.com. Email: kdoherty@mjhlifesciences.com

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Retifanlimab demonstrated durable activity with a tolerable safety profile in patients with chemotherapy-naive MCC.

Retifanlimab Adds FDA-Approved Option to Merkel Cell Carcinoma Treatment Landscape

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Megan Melody, MD, discusses how embracing authenticity, building patient trust, and supporting fellow female oncologists are key to thriving in the field.

Embracing Authenticity and Fostering Community Are Essential for Empowering Women in Oncology

A discovery by researchers from Mayo Clinic may help explain why immunotherapy hasn't been helpful for many patients with metastatic colorectal cancer.

Mayo Clinic Researchers Identify Proteins Linked to Immunotherapy Resistance in Metastatic Colorectal Cancer

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Recent Advances in Molecular Biomarkers in Multiple Myeloma

Medical Content

Videos

Dr Shaji Kumar and Dr Jonathan Kaufman discuss the evolving role of biomarkers in multiple myeloma.

Jonathan Kaufman, MD, provides an overview of multiple myeloma (MM) and reviews current biomarkers and molecular pathways commonly seen in MM.

Biomarkers in Multiple Myeloma (MM): Overview

Dr Shaji Kumar explains the role of t(11;14) translocation in patients with multiple myeloma and discusses treatment options for this specific population.

Role of t(11;14) Translocation in Patients with MM

Drs Shaji Kumar and Jonathan Kaufman review the BELLINI trial, as well as provide an overview of other investigational studies of BCL2 inhibitors for the treatment of patients with t(11;14) translocation with relapsed refractory multiple myeloma.

Evidence Around BCL2 Inhibitors for Patients with t(11;14) Translocation in MM

Shaji Kumar, MD, talks about new biomarkers that are being explored in patients with multiple myeloma.

Emerging Biomarkers in Multiple Myeloma

Two experts review strategies and barriers to overcome for biomarker testing in patients with multiple myeloma.

Testing for Biomarkers in Multiple Myeloma

Shaji Kumar, MD and Jonathan Kaufman, MD, discuss unmet needs in the multiple myeloma treatment landscape and share their insights on testing for biomarkers.

Future Perspectives in Biomarker Identification and Testing in MM

OncLive Insights

Biomarkers in Multiple Myeloma (MM): Overview

EP: 1.Biomarkers in Multiple Myeloma (MM): Overview

EP: 2.Role of t(11;14) Translocation in Patients with MM

EP: 3.Evidence Around BCL2 Inhibitors for Patients with t(11;14) Translocation in MM

EP: 4.Emerging Biomarkers in Multiple Myeloma

EP: 5.Testing for Biomarkers in Multiple Myeloma

EP: 6.Future Perspectives in Biomarker Identification and Testing in MM

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