CNS Disease

This segment covers central nervous system (CNS) involvement in EGFR-mutated NSCLC. The panelists discuss how large, symptomatic brain involvement warrants consult of radiation and neurosurgery colleagues, while small, asymptomatic brain metastases may reasonably be treated with systemic therapy. CNS disease is a high-risk feature favoring combination therapy, and the importance of obtaining MRI of the brain is emphasized given the risk of missing occult brain metastasis.