|Videos|August 10, 2020

Colorectal Cancer Updates

Author(s)Yelena Y. Janjigian, MD, Memorial Sloan Kettering Cancer Center, Jaffer A. Ajani, MD, MD Anderson Cancer Center, Daniel Catenacci, MD, University of Chicago Medicine

Insight regarding updates to the management of patients with colorectal cancer who are microsatellite instability-high (MSI-H)/mismatch repair deficient, harbor a BRAF V600E rare mutation, or have a HER2-expressing tumor.

Data from the following clinical trials is discussed:

Pembrolizumab vs chemotherapy for MSI-H/mismatch repair deficient metastatic colorectal cancer: The phase 3 KEYNOTE-177 study. (Andre T, et al. ASCO 2020. LBA4)
Encorafenib plus cetuximab +/- binimetinib for BRAF V600E metastatic colorectal cancer: BEACON CRC updated survival results (Kopetz S, et al. ASCO 2020. Abstract 4001)
A phase 2, multicenter, open-label study of trastuzumab deruxtecan (T-DXd; DS-8201) in patients (pts) with HER2-expressing metastatic colorectal cancer (mCRC): DESTINY-CRC01. (Siena S, et al. ASCO 2020. Abstract 4000)

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Pembrolizumab vs chemotherapy for MSI-H/mismatch repair deficient metastatic colorectal cancer: The phase 3 KEYNOTE-177 study. (Andre T, et al. ASCO 2020. LBA4)

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