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Othman Al-Sawaf, MD, discusses the benefit of fixed-duration treatment with obinutuzumab plus venetoclax in chronic lymphocytic leukemia.
Othman Al-Sawaf, MD, physician, the University Hospital of Cologne, discusses the benefit of fixed-duration treatment with obinutuzumab (Gazyva) plus venetoclax (Venclexta) in chronic lymphocytic leukemia (CLL).
In the phase 3 CLL14 trial (NCT02242942), investigators evaluated the efficacy and safety of fixed-duration obinutuzumab plus venetoclax vs obinutuzumab plus chlorambucil in patients with previously untreated CLL with preexisting conditions.
Five-year follow-up data showed that fixed-duration obinutuzumab plus venetoclax demonstrated a clear benefit, particularly regarding toxicity, Al-Sawaf says. Since adverse effects were observed only when patients were on treatment, the lack of prolonged toxicity gives fixed-duration treatment another advantage, Al-Sawaf concludes.